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KMID : 0360319920240030401
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Journal of Korean Cancer Research Association
1992 Volume.24 No. 3 p.401 ~ p.410
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Palliative Chemotherapy of Soft Tissue Sarcoma with Adriamycin and Dacarbazine(ADIC) and Cyclophosphamide, Vincristine, Adriamycin and Dacarbazin(CVVADIC)
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박영석
강원기/서창인/김흥태/김효진/박근칠/허대석/방영주/김노경
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Abstract
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Between January 1981 and April 1989, the combination chemotherapy with adriamycin and dacarbazine(ADIC) or cyclophosphamide, vincristine, adriamycin and dacarbazine(CYVADIC) has been administered in 39 patients with recurrent or metastatic soft
tissue
sarcoma. In ADIC group, 3 patients(13.6%) achieved complete response and 3 patients(13.6%) had partial response among 22 evaluable patients. In CYVADIC group, 2 patients(12.5%) achieved parital response among 16 evaluable patients, the median
time
to
progression was 2.6 months for ADIC group and 2.7 months for CYVADIC group. The median survival of all patients was 7.5 months, and patients of ADIC group had a longer survival than those of CYVADIC group(21 versus 7.4 months). However, there
were
no
significant differences between two groups in terms of response rate and median survival. The main toxicities were nausea/vomiting, alopecia and myelosuppression, but these were acceptable and did not differ significantly between the two
regimens.
We
didn't find any significant prognostic factors influencing response rate or survival. In conclusion, a combination chemotherapy of adriamycin and dacarbazine in patients with soft tissue sarcoma seemed to be active and well tolerated, but there
was
no
significant difference between treatment groups with respect to response rate and survival.
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KEYWORD
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